MRS 2578

Research use only, not for human use.

MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.

MRS-2578 is a selective antagonist of P2Y6 nucleotide receptors (IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively). Activation of P2Y6 receptor amplifies mucosal adenosine triphosphate release underlying bladder overactivity in patients with benign prostatic hyperplasia. Therefore, selective P2Y6 receptor blockade as a novel therapeutic strategy is potentially useful to control persistent storage symptoms in obstructed patients.

MRS-2578; MRS2578; MRS 2578

Others

Other Targets

P2Y6

Cardiovascular Disease

——

711019-86-2

472.67

C20H20N6S4

98%

DMSO : ≥ 80 mg/mL; 169.25 mM

S=C=NC1=CC=CC(NC(=S)NCCCCNC(=S)NC2=CC(=CC=C2)N=C=S)=C1

1,1'-(butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)

(-20℃)

With Ice Pack

≥ 2 years